Our scientific understanding of Autism as a biologically-based, treatable disorder has evolved a great deal in recent years, bringing the promise of new hope and development of effective treatments to those who are affected.
Over time, what has emerged is a complicated amalgam of metabolic abnormalities, including mitochondrial dysfunction, immune dysregulation, inflammation, oxidative stress, methylation problems, transsulfuration issues and toxicity in ASD. Dr. Daniel Rossignol and Dr. Richard Frye recently published a review article where they searched the world’s medical literature to identify how many studies implicated these biochemical abnormalities in ASD. Here’s what they found:
- 437 publications examined immune dysregulation or inflammation in ASD; 416 (95%) found an association
- 115 publications examined oxidative stress in ASD; all 115 found an association
- 153 publications examined mitochondrial dysfunction in ASD; 145 (95%) reported an association
- 190 publications examined environmental toxicant exposures in ASD; 170 (89%) found an association
- 62% of the publications in these 4 areas were published in the last 5 years (2006-2010)
- Genetic studies were the most common type of study in the medical literature concerning ASD; these studies accounted for more studies (1,576) than these 4 areas combined
For an extensive, categorized list of relevant research, please visit the Autism Research Institute.